Review of China’s Difenoconazole Performance in 2012

Difenoconazole is a triazole fungicide which was developed by Syngenta, it’s widely used for its characters of novelty, efficiency and safety. Its global annal sales reached some $200 million, ranked 3rd  on the list of triazole fungicides. Difenoconazole inhibits biosynthesis of the cell wall polyhydric alcohols to prevent growth of fungi, such mode of action makes it a protective, therapeutic and systemic fungicide. Its security is relatively high in triazole fungicides. Difenoconazole is widely used in fruit and vegetable to prevent scab of cucurbits, grape bitter rot, black pox, white rot, leaf spot, powdery mildew, leaf spot, rust, stripe rust, scab, etc. It provides long-lasting preventive and curative activity against ascomycetes, basidiomycetes and deuteromycetes including alternaria, ascochyta, cercospora, cercosporidium, colletotrichum, guignardia, mycosphaerella, phoma, ramularia, rhizoctonia, septoria, uncinula, venturia spp and some seed-borne pathogens.
In recent years, the annal sales of difenoconazole were more than $100 million. Back in 2003, the annal sales was $110 million. Two years later, it increased to $135 million. In 2007, the annal turnover reached $195 million, till the year of 2009, this number exceeded $200 million, reached $210 million.

In the fourth quarter of 2010, the price of difenoconazole was 192000 yuan/ton,since then, the price began rising steadily to 210000 yuan/ton and floated up and down around this level. Currently, it shows a rapidly growth trend of domestic production, demand and export, which indicates that Difenoconazole is coming into a phase of rapid development in domestic. According to statistics, in the first half of 2012, the production of difenoconazole is 1065.29 tons, sales volume is 657.99 tons and export is 739.41 tons.

In recent years, the production capacity of difenoconazole expanded more quickly than before. Since Syngenta first registered in China, there has been a quick increase in domestic registered manufacturers. Up till now, there have been 13 pesticide enterprises registered for manufacturing difenoconazole technical products. Since most manufacturers which were built up during 2005 to 2007 were in small scale, like 100-150 tons per year, along with the good trend in domestic, many enterprises planed to expand and construct new plants. For instance, Gengyun Company of Jiangsu Province moved to International Chemical Industrial Park in Zhenjiang Economic and Technological Development Zone, the scale of production reached 1000 tons/year. Currently, the production capacity of difenoconazole is more than 3500 tons/year.

Demand of difenoconazole increased quickly. In the past few years, since the factors of price and promotion, difenoconazole was mainly used on fruit and vegetable, the market was in a mode of equilibriumapp:addword:equilibrium. According to some regions’ Plant Protection Departments, three main factors may push the demand of difenoconazole. Firstly, in recent years, some main crop cultivars are poor in disease-resistance and some disease are serious. Secondly, the price of fruit and vegetable rises steadily, planting benefit is obviously good. Thirdly, although the price of difenoconazole is on a high level, its use is only one tenth to one fifth of thiocarbamates and dithane, thus the residue is relatively much lower. Plus, so far, no resistance cases have been reported on difenoconazole.

Now difenoconazole is registered on a peak time in China. 10% WDG was registered in China for scab on pears and black spot on cabbages in 1999, certificate No. LS99008. Companies began to develop this product ever since, till now there are more than 220 products under difenoconazole.

Currently registered difenoconazole single-TC formulations, see next form:

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